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Title   부인암 환자에 있어서 항암화학요법후 유발되는 호중구 감소증에 대한 Thymomodulin 의 임상적 효용성 ( Clinical Efficacy of Thymomodulin on Neutropenia Induced by Chemotherapy in the Patients with Gynecologic Cancer )
Publicationinfo   1993 Jan; 025(06): 956-966.
Key_word   Thymomodulin, Cytotoxic chemotherapy, Neutropenia
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Abstract   Thymomodulin(thymus extract, Leucon) has been shown to be effective in accelerating the recovery of neutropenia following a variety of chemotherapeutic regimens. In this study we evaluated the efficacy and safety of Thymomodulin in the patients with neutropenia before and/or after chemotherapy for gynecological cancers. Forty patients(cervical cancer, 20; ovarian cancer, 20) who were undergoing treatment with cytotoxic chemotherapy were selected and divided into two groups acccording to the number of leukocyte before chemotherapy. Leukocyte count was normal or higher in group I(20), and already neutropenic in group II(20) before chemotherapy. Thymomodulin(15 ml/day) was administered to the l0 patients in each group for 15 days from the first day of chemotherapy and its effect were compared to that of placebo in 10 control patients in each group. There was no statistically significant difference in the nadir of the neutropenia after chemotherapy between Thymomodulin-treated and control patients in both groups. But duration of neutropenia and recovery from it were slightly shortened in Thymomodulin-treated patients in both group. The incidence of febrile neutropenia was not lower in the Thymomodulin-treated patients than in the control patients. No remarkable adverse effect of the Thymomodulin administration was observed. In conclusion, Thymomodulin may be useful in accelerating the recovery of neutropenia induced by cytotoxic chemotherapy in patients with gynecoiogical cancer.
저 자   김병기(Byoung Kee Kim),고창원(Chang Won Koh),김종혁(Jong Hyeok Kim),송용상(Yong Sang Song),강순범(Soon Beom Kang),이효표(Hyo Pyo Lee)